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Are Toxicological Responses in Laboratory (Inbred) Zebrafish Representative of Those in Outbred (Wild) Populations? − A Case Study with an Endocrine Disrupting Chemical

✍ Scribed by Brown, A. Ross; Bickley, Lisa K.; Le Page, Gareth; Hosken, David John; Paull, Gregory C.; Hamilton, Patrick B.; Owen, Stewart F.; Robinson, Joanna; Sharpe, Alan D.; Tyler, Charles R.

Book ID: 120903680
Publisher: American Chemical Society
Year: 2011
Tongue: English
Weight: 857 KB
Volume: 45
Category: Article
ISSN: 0013-936X
DOI: 10.1021/es200122r

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Are Toxicological Responses in Laborator

Are Toxicological Responses in Laboratory (Inbred) Zebrafish Representative of Those in Outbred (Wild) Populations? − A Case Study with an Endocrine Disrupting Chemical

✍ Brown, A. Ross; Bickley, Lisa K.; Le Page, Gareth; Hosken, David John; Paull, Gr 📂 Article 📅 2011 🏛 American Chemical Society 🌐 English ⚖ 857 KB

Laboratory animals tend to be more inbred and less genetically diverse than wild populations, and thus may differ in their susceptibility to chemical stressors. We tested this hypothesis by comparing the responses of related inbred (theoretical inbreeding F(IT) = n + 0.25) and outbred (F(IT) = n) ze