Are the classification criteria for psoriatic arthritis better than existing criteria for diagnosing psoriatic arthritis? Comment on the article by Taylor et al

✍ Scribed by Dennis McGonagle; Ai Lyn Tan

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 40 KB
• Volume: 56
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.22411

✦ Synopsis

measured in a more accessible compartment, are a compatible surrogate for the hormonal environment of the knee joint.

This new information also does not yet establish whether our observed associations represent the response to a receptor-mediated process (as in the case of lower estradiol concentrations) or a cytokine-based response (as in the lower urinary 2-hydroxyestrone concentrations), or potentially, both mechanisms. There is little evidence that 2-hydroxyestrogens have binding affinity to the estrogen receptor (4,5), but they appear to have additional important properties, including participation in oxidation/reduction actions (6), and may modulate arachidonic acid metabolism and the cyclooxygenase 1 (COX-1) and COX-2 enzymes.