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Are the catecholestrogens involved in estrogen-induced striatal dopamine receptor supersensitivity?

✍ Scribed by Carlo Ferretti; Piera Ghi; Marinella Blengio; Guido Gaietta; Giuseppina Barrera; Enrico Genazzani

Book ID
115882096
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
600 KB
Volume
166
Category
Article
ISSN
0014-2999

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Clozapine and molindone administered to mice for 21 days did not elevate the density of striatal 3H-spiperone binding sites at doses clinically equivalent to 1.5 mg/kg haloperidol, which elevated binding by 29%. Thioridazine (25 mg/kg) elevated binding by 25%. It appears that clinically equivalent d