Are senescence and exhaustion intertwine
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Akbar, Arne N.; Henson, Sian M.
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Article
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2011
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Nature Publishing Group
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English
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Can the immune system be reactivated continuously throughout the lifetime of an organism or is there a finite point at which repeated antigenic challenge leads to the loss of lymphocyte function or the cells themselves or both? Replicative senescence and exhaustion are processes that control T cell