Are poly(ADP-ribosyl)ation by PARP-1 and deacetylation by Sir2 linked?

Co-localization of poly(ADPR)polymerase

Co-localization of poly(ADPR)polymerase 1 (PARP-1) poly(ADPR)polymerase 2 (PARP-2) and related proteins in rat testis nuclear matrix defined by chemical cross-linking

✍ Filomena Tramontano; Silvia Di Meglio; Piera Quesada 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 229 KB

## Abstract Poly(ADPR)polymerase 1 and 2 (PARP‐1, PARP‐2) are nuclear enzymes which function is based on specific interactions with DNA and nuclear proteins. PARPs targets include proteins involved in DNA replication, repair, and transcription and their function can be modulated either by protein–p