Are [O-methyl-11C]derivatives of ICI 89,406 β1-adrenoceptor selective radioligands suitable for PET?

Synthesis of (R)- and (S)-[O-methyl-11C]

Synthesis of (R)- and (S)-[O-methyl-11C]N-[2-[3-(2-cyano-phenoxy)-2-hydroxy-propylamino]-ethyl]-N′-(4-methoxy-phenyl)-urea as candidate high affinity β1-adrenoceptor PET radioligands

✍ Stefan Wagner; Marilyn P. Law; Burkhard Riemann; Victor W. Pike; Hans-Jörg Breyh 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 French ⚖ 148 KB 👁 1 views

Molecular imaging and quantification of myocardial b 1 -adrenoceptor (AR) rather than total b-AR density is of great clinical interest since cardiac biopsy studies suggest that myocardial b 1 -AR density is reduced in patients with chronic heart failure whereas cardiac b 2 -AR density may vary. Posi