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Are dislocated metaphase chromosomes and loss of kinetochores involved in the genesis of aneuploidy?

✍ Scribed by D. Schiffmann; S. Kirchner; D.H. Yung; T. Papp; H. Stopper; B.K. Vig


Book ID
113252508
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
80 KB
Volume
271
Category
Article
ISSN
0165-1161

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The most frequent genetic aberration found in transitional cell carcinoma (TCC) of the bladder involves chromosome 9. Loss of heterozygosity (LOH) analyses show deletions of both chromosome 9p and 9q, while in situ hybridization studies suggest a significant percentage of tumours with monosomy 9. To