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Architecture and anatomy of the genomic locus encoding the human leukemia-associated transcription factor RUNX1/AML1

✍ Scribed by Ditsa Levanon; Gustavo Glusman; Thorsten Bangsow; Edna Ben-Asher; Dean A Male; Nili Avidan; Carmen Bangsow; Masahira Hattori; Todd D Taylor; Stefan Taudien; Karin Blechschmidt; Nobuyoshi Shimizu; Andre Rosenthal; Yoshiyuki Sakaki; Doron Lancet; Yoram Groner

Book ID
117520175
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
556 KB
Volume
262
Category
Article
ISSN
0378-1119

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The transcription factor RUNX1 is a key regulator of haematopoiesis in vertebrates. In humans, the 260-kb long gene coding for this transcription factor is located on chromosome 21. This gene is transcribed from two alternative promoters that are commonly referred to as the distal and the proximal p