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Arachidonic acid may serve as a second messenger in interleukin-1 induced collagenase production by chondrocytes


Book ID
114348801
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
138 KB
Volume
1
Category
Article
ISSN
1063-4584

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We studied the long-terms effects of interleukin-1beta (IL-1beta; 3 to 6 h) on alpha-(methylamino) isobutyric acid (MeAIB), a nonmetabolizable amino acid transported by system A. We found that IL-1beta induced a large decrease in MeAIB uptake by human osteoarthritic synovial cells and a concomitant