Aquaporin-1 gene deletion reduces breast tumor growth and lung metastasis in tumor-producing MMTV-PyVT mice

Enhanced tumorigenesis and reduced trans

Enhanced tumorigenesis and reduced transforming growth factor-β type II receptor in lung tumors from mice with reduced gene dosage of transforming growth factor-β1

✍ Yang Kang; Jennifer M. Mariano; Jerry Angdisen; Terry W. Moody; Bhalchandra A. D 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 306 KB 👁 1 views

To elucidate the role of transforming growth factor-beta1 (TGF-beta1) and the TGF-beta type II receptor (TGF-beta RII) as tumor-suppressor genes in lung carcinogenesis, we mated C57BL/6 mice heterozygous (HT) for deletion of the TGF-beta1 gene with A/J mice to produce AJBL6 TGF-beta1 HT progeny and