APvuII restriction fragment length polymorphism of the glucose-6-phosphate dehydrogenase gene is an African-specific marker
✍ Scribed by Martin F. Fey; Jim S. Wainscoat; E. C. Mukwala; A. G. Falusi; Tom J. Vulliamy; Lucio Luzzatto
- Book ID
- 104658885
- Publisher
- Springer
- Year
- 1990
- Tongue
- English
- Weight
- 194 KB
- Volume
- 84
- Category
- Article
- ISSN
- 0340-6717
No coin nor oath required. For personal study only.
✦ Synopsis
The site of a PvuII restriction fragment length polymorphism (RFLP) of the human glucose-6-phosphate dehydrogenase (G6PD) gene has been located in intron V, 60 bp upstream of G6PD exon VI. A population survey shows this RFLP to be specific for African populations, with frequencies of the rarer allele (PvuII type 2 site present) of 0.32-0.40 in Kenyans, Nigerians, Zambians, and West Indians. This allele has not been found in the European, Asian and Middle Eastern populations studied. Such population-specific markers may be useful in the study of population affinities and may provide insight into prehistoric migrations of peoples.