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Aprotinin stimulates angiogenesis and human endothelial cell migration through the growth factor pleiotrophin and its receptor protein tyrosine phosphatase β/ζ

✍ Scribed by Marina Koutsioumpa; Maria Hatziapostolou; Constantinos Mikelis; Pieter Koolwijk; Evangelia Papadimitriou

Book ID
113587999
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
641 KB
Volume
602
Category
Article
ISSN
0014-2999

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✍ Christos Polytarchou; Maria Hatziapostolou; Evangelia Poimenidi; Constantinos Mi 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 French ⚖ 654 KB

## Abstract Pleiotrophin (PTN) is a secreted growth factor involved in angiogenesis and tumor growth. We have recently shown that low concentrations of hydrogen peroxide (HP) stimulate PTN expression, through activation of the transcription factor AP‐1. In the present work, we studied the possible