Germline mutations in the BRCA1 and BRCA2 genes are responsible for the predisposition and development of familial breast and/or ovarian cancer. Most mutations of BRCA1 and BRCA2 associated with breast and/or ovarian cancer result in truncated proteins. To investigate the presence of BRCA1 and BRCA2
Appropriateness of breast-conserving treatment of breast carcinoma in women with germline mutations in BRCA1 or BRCA2 : A clinic-based series
β Scribed by Mark Robson; Tiffany Svahn; Beryl McCormick; Patrick Borgen; Clifford A. Hudis; Larry Norton; Kenneth Offit
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 138 KB
- Volume
- 103
- Category
- Article
- ISSN
- 0008-543X
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π SIMILAR VOLUMES
## Abstract We used mathematical models to analyze the ageβincidence curve of breast carcinoma for individuals carrying a germline mutation in the BRCA1 or BRCA2 gene locus. Although many genomic abnormalities have been identified in breast tumors, we found that a twoβstage model fit the data well.
## BACKGROUND. The purpose of this investigation was to elucidate the clinicopathologic characteristics of BRCA1-and BRCA2-associated hereditary breast carcinomas (HBCs) in Japanese women.