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Approaches to the Synthesis of Some Tyrosine-Derived Marine Sponge Metabolites: Synthesis of Verongamine and Purealidin N

✍ Scribed by Boehlow, Todd R.; Harburn, J. Jonathan; Spilling, Christopher D.


Book ID
120535787
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
196 KB
Volume
66
Category
Article
ISSN
0022-3263

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Fascaplysin 1, an antimicrobial and cytotoxic red pigment of the marine sponge Fascaplysinopsis sp.. has been synthesized in five steps from tryptamine 2 in 44% overall yield. The key steps in the synthesis are: (a) dehydrogenation of the dihydro-13-.carboline intermediate 4 simultaneously with its