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Approaches to Enzyme and Substrate Design of the Murine Dnmt3a DNA Methyltransferase

✍ Scribed by Renata Z. Jurkowska; Abu Nasar Siddique; Tomasz P. Jurkowski; Prof. Dr. Albert Jeltsch


Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
461 KB
Volume
12
Category
Article
ISSN
1439-4227

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## Abstract To explore the role of DNA methylation in the brain, we examined the expression pattern of de novo DNA methyltransferases Dnmt3a and Dnmt3b in the mouse central nervous system (CNS). By comparing the levels of Dnmt3a and Dnmt3b mRNAs and proteins in the CNS, we showed that Dnmt3b is det