An efficient strategy for the rapid construction of the guiane bicyclo[5.3.0]decane ring system from appropriately substituted 4-alkyn-1-ols has been developed. This methodology relies on a MeLi-catalyzed tandem 5-exo-dig cyclization/Claisen rearrangement sequence as the key ring forming step.
Approach to the Synthesis of Diterpenes with the Bicyclo[5.3.0]decane System: (±) 10-epi-tormesol
✍ Scribed by Isidro S. Marcos; Isabel M. Oliva; David Díez; Pilar Basabe; Anna M. Lithgow; Rosalina F. Moro; Narciso M. Garrido; Julio G. Urones
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 856 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0040-4020
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