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Applying the Taguchi robust design to the optimization of the asymmetric reduction of ethyl 4-chloro acetoacetate by bakers’ yeast

✍ Scribed by Jer-Yiing Houng; Hsia-Fen Hsu; Yung-Hau Liu; Jiumn-Yih Wu


Book ID
119524272
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
206 KB
Volume
100
Category
Article
ISSN
0168-1656

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✍ Yu-gang Shi; Yun Fang; Yue-ping Ren; Hui-lei Guan; Jing-Yang Zhang 📂 Article 📅 2009 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 135 KB

## Abstract **BACKGROUND:** The enantioselectivity of reduction of ethyl 2‐oxo‐4‐phenylbutyrate (EOPB) to synthesize ethyl (__R__)‐2‐hydroxy‐4‐phenylbutyrate ((__R__)‐EHPB) catalyzed with baker's yeast in diethyl ether can be improved by the introduction of alpha‐phenacyl chloride (PC). However, th