✦ LIBER ✦

Applying Mosher's method to acetogenins bearing vicinal diols. The absolute configurations of muricatetrocin C and rollidecins A and B, new bioactive acetogenins from Rollinia mucosa

✍ Scribed by Guoen Shi; Zhe-ming Gu; Kan He; Karl V. Wood; Lu Zeng; Qing Ye; John M. MacDougal; Jerry L. McLaughlin

Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 588 KB
Volume: 4
Category: Article
ISSN: 0968-0896
DOI: 10.1016/0968-0896(96)00114-9

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✦ Synopsis

Muricatetrocin C (l), rollidecin A (2), and rollidecin B (3), three new bioactive annonaceous acetogenins bearing vicinal diols, were isolated from the leaves of Rollinia mucosa (Annonaceae) using activity-directed fractionation. The total structural elucidations of 1-3, including the absolute stereochemistries of the vicinal diols, were achieved by analyzing their per-Mosher ester derivatives. All three compounds showed potent and selective inhibitory effects against several human cancer cell lines.