Applied Cross-Coupling Reactions

✍ Scribed by Yaushi Nishihara (auth.), Yasushi Nishihara (eds.)

• Publisher: Springer-Verlag Berlin Heidelberg
• Year: 2013
• Tongue: English
• Leaves: 245
• Series: Lecture Notes in Chemistry 80
• Edition: 1
• Category: Library

✦ Synopsis

“Applied Cross-Coupling Reactions” provides students and teachers of advanced organic chemistry with an overview of the history, mechanisms and applications of cross-coupling reactions. Since the discovery of the transition-metal-catalyzed cross-coupling reactions in 1972, numerous synthetic uses and industrial applications have been developed. The mechanistic studies of the cross-coupling reactions have disclosed that three fundamental reactions: oxidative addition, transmetalation, and reductive elimination, are involved in a catalytic cycle. Cross-coupling reactions have allowed us to produce a variety of compounds for industrial purposes, such as natural products, pharmaceuticals, liquid crystals and conjugate polymers for use in electronic devices. Indeed, the Nobel Prize for Chemistry in 2010 was awarded for work on cross-coupling reactions. In this book, the recent trends in cross-coupling reactions are also introduced from the point of view of synthesis design and catalytic activities of transition-metal catalysts.

✦ Table of Contents

Front Matter....Pages i-x
Front Matter....Pages 1-1
A Historic Overview of the Metal-Catalyzed Cross-Coupling Reactions....Pages 3-15
Mechanisms and Fundamental Reactions....Pages 17-39
Front Matter....Pages 41-41
Natural Product Synthesis....Pages 43-83
Pharmaceuticals....Pages 85-109
Liquid Crystals....Pages 111-135
Conjugated Polymers....Pages 137-173
Front Matter....Pages 175-175
Recent Advances in Cross-Coupling Reactions with Aryl Chlorides, Tosylates, and Mesylates....Pages 177-202
Recent Advances in Cross-Coupling Reactions with Alkyl Halides....Pages 203-229
Back Matter....Pages 231-245

✦ Subjects

Organometallic Chemistry; Industrial Chemistry/Chemical Engineering; Polymer Sciences