Applications of tandem mass spectrometry to the characterization of derivatized glutathione conjugates. Studies with S-(N-Methylcarbamoyl)-glutathione, a metabolite of the antineoplastic agent N-methylformamide

Studies on the formation of reactive int

Studies on the formation of reactive intermediates from the antineoplastic agent N,N′Bis(2-chloroethyl)-N-nitrosourea (BCNU) in vitro and in Vivo. Characterization of novel glutathione adducts by ionspray tandem mass spectrometry

✍ Margaret R. Davis; Thomas A. Baillie 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 960 KB

In a study designed to examine the nature of short-lived, electrophilic intermediates liberated during decomposition of N,N'-bis(2-chloroethyI)-N-nitrosourea (BCNU) in vitro and also on administration of BCNU (140 pmol i.p.) to rats in vivo, both on-line and off-line LC/MS/MS techniques were employe