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Applications of model β-hairpin peptides

✍ Scribed by Carol E. Stotz; Elizabeth M. Topp

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
191 KB
Volume
93
Category
Article
ISSN
0022-3549

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✦ Synopsis

In recent years, b-hairpin peptides have been studied in great detail. Much of the focus has been on the thermodynamic stability of b-hairpin structure. Structural measurements have been conducted with nuclear magnetic resonance, with additional information obtained from circular dichroism, Fourier transform infrared, and molecular dynamic simulation studies. Point mutations, both in the b-strands and in the turn region, have systematically explored the role of turn sequence, side-chain-sidechain interactions, intramolecular hydrogen bonding, and b-strand length on b-hairpin peptide conformational stability. In addition to studying the elements of structural stability independently, the cooperative nature of the individual components to combine to form the overall structure has also been investigated. Because the b-hairpin peptides often spontaneously form their conformation, they have begun to serve as models for studying peptide binding and therapeutic agents.

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