Applications of microsatellite-based Y chromosome haplotyping

✍ Scribed by Manfred Kayser; Peter De Knijff; Patrick Dieltjes; Michael Krawczak; Marion Nagy; Tatiana Zerjal; Arpita Pandya; Chris Tyler-Smith; Lutz Roewer

• Book ID: 102834781
• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 602 KB
• Volume: 18
• Category: Article
• ISSN: 0173-0835
• DOI: 10.1002/elps.1150180920

✦ Synopsis

Applications of microsatellite-based Y chromosome haplotyping

Y-chromosomal microsatellites have been investigated for the purposes of application to male identification, population genetics and population history. With nine markers, every male in a German population sample (n = 70) could be identified by an individual-specific Y microsatellite haplotype. The analysis of 474 unrelated males of nine human populations with seven markers revealed 301 different Y haplotypes. The analysis of molecular variance (AMOVA) approach was used to detect male population characteristics of Y microsatellite haplotypes. With pairwise comparisons of inter-population variance, most of the populations could be distinguished significantly. Sixty individuals from different male populations in Asia and Northern Europe carrying a novel Y-chromosomal T+C transition show reduced microsatellite variability together with haplotype similarities. Microsatellite data suggest that the mutation occurred recently in Asia, supporting the hypothesis of Asian ancestry of some northern European populations.