The objectives of this study are: (i) to evaluate the predictive performance of interspecies scaling for antibodies to predict clearance, volume of distribution at steady state, and half-life in humans from animal data and (ii) to estimate first-inhuman dose based on the predicted human clearance. F
โฆ LIBER โฆ
Applications of Human Pharmacokinetic Prediction in First-in-Human Dose Estimation
โ Scribed by Peng Zou; Yanke Yu; Nan Zheng; Yongsheng Yang; Hayley J. Paholak; Lawrence X. Yu; Duxin Sun
- Book ID
- 118728996
- Publisher
- American Association of Pharmaceutical Scientists
- Year
- 2012
- Tongue
- English
- Weight
- 442 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1550-7416
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The aim of this study was to assess the pharmacokinetic profile of pancopride after repeated oral dose administration of 20mg pancopride in tablet form once a day for 5 d in 12 healthy male volunteers. Plasma levels were measured by HPLC using a solid phase extraction method and automated injection.