𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Applications of gene targeting technology to mental retardation and developmental disability research

✍ Scribed by Pimenta, Aurea F. ;Levitt, Pat

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
274 KB
Volume
11
Category
Article
ISSN
1080-4013

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The human and mouse genome projects elucidated the sequence and position map of innumerous genes expressed in the central nervous system (CNS), advancing our ability to manipulate these sequences and create models to investigate regulation of gene expression and function. In this article, we reviewed gene targeting methodologies with emphasis on applications to CNS development and neurodevelopmental disorders. © 2005 Wiley‐Liss, Inc. MRDD Research Reviews 2005;11:295–302.

📜 SIMILAR VOLUMES

Goodness-of-fit ethic for informed conse
Goodness-of-fit ethic for informed consent to research involving adults with mental retardation and developmental disabilities
✍ Fisher, Celia B. 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 93 KB

## Abstract This article reviews current theory and research on informed consent policies for adults with mental retardation within a relational ethics framework that re‐conceptualizes consent vulnerability in terms of the goodness‐of‐fit between participant decisional capacities and the specific c

The contribution of novel brain imaging
The contribution of novel brain imaging techniques to understanding the neurobiology of mental retardation and developmental disabilities
✍ Gothelf, Doron ;Furfaro, Joyce A. ;Penniman, Lauren C. ;Glover, Gary H. ;Reiss, 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 299 KB

## Abstract Studying the biological mechanisms underlying mental retardation and developmental disabilities (MR/DD) is a very complex task. This is due to the wide heterogeneity of etiologies and pathways that lead to MR/DD. Breakthroughs in genetics and molecular biology and the development of sop

Application of metaphase HR-CGH and targ
Application of metaphase HR-CGH and targeted chromosomal microarray analyses to genomic characterization of 116 patients with mental retardation and dysmorphic features
✍ B. Nowakowska; P. Stankiewicz; E. Obersztyn; Z. Ou; J. Li; A.C. Chinault; M. Smy 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 157 KB

## Abstract Recent advances in molecular cytogenetics enable identification of small chromosomal aberrations that are undetectable by routine chromosome banding in 5–20% of patients with mental retardation/developmental delay (MR/DD) and dysmorphism. The aim of this study was to compare the clinica