Ligand exchange reaction of sulfoxides i
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Tsuyoshi Satoh; Hideaki Unno; Yasuhiro Mizu; Yasumasa Hayashi
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Article
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1997
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Elsevier Science
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French
β 624 KB
A novel two-step procedure for one-carbon homologation of methylesters to esters, thioesters, carboxylic acids and amides is described. Methylesters are reacted with lithium carbanion of chloromethyl phenyl sulfoxide to give a-chloro a-sulfinyl ketones in 70 to 90% yields. Potassium enolate of the a