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Application of toxicogenomics to study mechanisms of genotoxicity and carcinogenicity

✍ Scribed by Heidrun Ellinger-Ziegelbauer; Jiri Aubrecht; Jos C. Kleinjans; Hans-Juergen Ahr


Book ID
119380728
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
829 KB
Volume
186
Category
Article
ISSN
0378-4274

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Toxicogenomics technology defines toxicity gene expression signatures for early predictions and hypotheses generation for mechanistic studies, which are important approaches for evaluating toxicity of drug candidate compounds. A large gene expression database built using cDNA microarrays and liver s