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Application of Thiol−Olefin Co-oxygenation Methodology to a New Synthesis of the 1,2,4-Trioxane Pharmacophore

✍ Scribed by O'Neill, Paul M.; Mukhtar, Amira; Ward, Stephen A.; Bickley, Jamie F.; Davies, Jill; Bachi, Mario D.; Stocks, Paul A.


Book ID
123621094
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
81 KB
Volume
6
Category
Article
ISSN
1523-7060

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Regioselective Mukaiyama hydroperoxysily
✍ Paul M O'Neill; Matthew Pugh; Jill Davies; Stephen A Ward; B.Kevin Park 📂 Article 📅 2001 🏛 Elsevier Science 🌐 French ⚖ 85 KB

Co(II)-mediated peroxysilylation of allylic alcohols 6 or 9 regioselectively provides peroxysilyl alcohols 7 and 10 in good yield. Reaction of these peroxysilyl alcohols with aldehydes or ketones provides target 1,2,4-trioxanes in good to excellent yields. The sequence of Markovnikov hydroperoxysily