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Application of the Suzuki Reaction as the Key Step in the Synthesis of a Novel Atropisomeric Biphenyl Derivative for Use as a Liquid Crystal Dopant

✍ Scribed by Cammidge, Andrew N.; Crépy, Karen V. L.


Book ID
118263734
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
89 KB
Volume
68
Category
Article
ISSN
0022-3263

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Application of the Suzuki Reaction as th
✍ Cammidge, Andrew N.; Crépy, Karen V. L. 📂 Article 📅 2003 🏛 American Chemical Society 🌐 English ⚖ 89 KB

A heavily functionalized atropisomeric biphenyl derivative (4), which is designed to possess a large lateral dipole moment, has been synthesized with use of a Suzuki coupling as the key step and resolved by chiral HPLC. The final coupling reaction is complicated by rapid hydrolytic deboronation of t