Application of the Suzuki Reaction as th
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Cammidge, Andrew N.; Crépy, Karen V. L.
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Article
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2003
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American Chemical Society
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English
⚖ 89 KB
A heavily functionalized atropisomeric biphenyl derivative (4), which is designed to possess a large lateral dipole moment, has been synthesized with use of a Suzuki coupling as the key step and resolved by chiral HPLC. The final coupling reaction is complicated by rapid hydrolytic deboronation of t