Application of the stable isotope technique to the elucidation of the saturation phenomenon of nicardipine hydrochloride metabolizing enzyme activity in dogs

The Use of Stable Isotope Labeling and L

The Use of Stable Isotope Labeling and Liquid Chromatography/Tandem Mass Spectrometry Techniques to Study the Pharmacokinetics and Bioavailability of the Antimigraine Drug, MK-0462 (Rizatriptan) in Dogs

✍ A. Barrish; T. V. Olah; G. J. Gatto; M. R. Dobrinska; J. D. Gilbert 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 428 KB 👁 2 views

## MK-0462 (rizatriptan) is a agonist being developed for the treatment of migraine. The assay for this substance in plasma and urine is based on HPLC with tandem mass spectrometry (MS/MS) detection. The procedure has been modified to include the simultaneous determination of the [triazole-"C,, "N3