Application of the lithium and magnesium initiators for the synthesis of glycolide, lactide, and ϵ-caprolactone copolymers biocompatible with brain tissue

✍ Scribed by Piotr Dobrzyński; Janusz Kasperczyk; Katarzyna Jelonek; Mirosław Ryba; Michał Walski; Maciej Bero

• Book ID: 102872175
• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: English
• Weight: 895 KB
• Volume: 79A
• Category: Article
• ISSN: 1549-3296
• DOI: 10.1002/jbm.a.30875

✦ Synopsis

Abstract

The subject of this work is new method of the synthesis of biodegradable copolymers compatible with brain tissue. Copolymerization of glycolide with lactide was conducted in solution or in bulk in the presence of LiBu, LiAcac, MgBu~2~, Mg(acac)~2~ as initiators. In all cases, copolymers with molecular weight of 20000–40000 were obtained, which enables to use them as drug carriers. During the reactions of copolymer chain growth, the intermolecular transesterification occurs, changing the distribution of comonomeric units in copolymer chain. Magnesium initiators showed a lower contribution to transesterification in comparison with lithium and calcium compounds. The copolymerization of glycolide with ε‐caprolactone using magnesium compounds as initiators was also described. The random glycolide/ε‐caprolactone copolymer (10/90) obtained with MgBu~2~ was used in in vivo study in the forms of microspheres and foils. Complete degradation of microspheres during 6 weeks was observed after the implantation to brain tissue. All implanted copolymers are compatible with brain tissue. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2006