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Application of the Gaussian mixture model to drug dissolution profiles prediction

✍ Scribed by Chee Peng Lim; Siow San Quek; Koh Khiang Peh

Publisher
Springer-Verlag
Year
2005
Tongue
English
Weight
339 KB
Volume
14
Category
Article
ISSN
0941-0643

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✍ Stephen G. Machatha; Samuel H. Yalkowsky πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 99 KB

A new bilinear function that accounts for the disparity between the log-linear and parabolic models for cosolvent solubilization is presented, where ethanol was used as the model cosolvent. This accounts for both the initial and terminal slopes in the ethanol/water solubility profiles of semi-polar