Application of the addition of triorganozincates to N-(tert-butanesulfinyl)imines to the enantioselective synthesis of α-amino acids

✍ Scribed by Raquel Almansa; David Guijarro; Miguel Yus

• Book ID: 104096597
• Publisher: Elsevier Science
• Year: 2009
• Tongue: French
• Weight: 265 KB
• Volume: 50
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2009.05.008

✦ Synopsis

Highly enantiomerically enriched N-protected a-amino acids can be easily prepared from optically pure N-(tert-butanesulfinyl)imines by a four-step sequence involving: diastereoselective addition of a triorganozincate to the imine, removal of the sulfinyl group, benzoylation of the nitrogen atom of the obtained