Application of the 2-adamantyloxycarbonyl (2-adoc) group to the protection of the imidazole function of histidine in peptide synthesis
โ Scribed by Nishiyama, Yasuhiro; Shintomi, Noriyuki; Kondo, Yukihiro; Okada, Yoshio
- Book ID
- 121313267
- Publisher
- The Royal Society of Chemistry
- Year
- 1994
- Tongue
- English
- Weight
- 304 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0022-4936
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๐ SIMILAR VOLUMES
The trltyl (Trt) group 1s ideally suited for the sjde-chain protection of His In peptide syntheses, in combination with 9-fluorenylmethyloxycarbonyl (Fmoc) In Na-and protecting groups cleavable by mild acidolysis in other poslt1ons of the peptide. 2,4,5-trlchlorophenyl (Tcp)-and pentafluorophenyl (P
Protection of the imidazole ring of the histidine residue is not required for the elongation of an oligonucleotide chain at the side chain hydroxyl group of an amino acid residue by the phosphite triester approach. For the assembly of the peptide chain, the 2,4-dinitrophenyl group is the best altern