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Application of terbium-sensitized luminescence for the determination of grepafloxacin in human urine and serum

✍ Scribed by Juan A. Ocaña; Manuel Callejón; Francisco José Barragán

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
121 KB
Volume
90
Category
Article
ISSN
0022-3549

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✦ Synopsis

Analytical performance and applications of a selective and sensitive lanthanide-sensitized luminescence method for the determination of grepa¯oxacin is described. The method is based in the time-resolved luminescence signal from a terbium (III)±grepa¯oxacin complex in a micellar solution of sodium dodecyl sulfate. The optimized method allows the determination of 10±500 ng mL À1 of grepa¯oxacin in 7.5 mM sodium dodecyl sulfate solution containing 0.16 M acetic acid±sodium acetate buffer (pH 6.0) and 7.5 mM Na 2 SO 3 (chemical deoxygenation agent), with l exc 275 nm and l em 546 nm. Grepa¯oxacin was determined in human serum (by external calibration method) and urine (by standard additions method), spiked at levels found after drug administration at normal clinical doses. Average recoveries found were 89.6 (relative standard deviation 0.9%) and 102 (relative standard deviation 2%), respectively.

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