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Application of syndiotacticity-rich PVA hydrogels to drug delivery system

✍ Scribed by S. Horiike; S. Matsuzawa

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 886 KB
Volume: 58
Category: Article
ISSN: 0021-8995
DOI: 10.1002/app.1995.070580815

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✦ Synopsis

The preparation of stable syndiotacticity-rich poly(viny1 alcohol) (s-PVA) hydrogels is easier in comparison with that of the atactic poly(viny1 alcohol) (a-PVA) hydrogels. The drug release with use of s-PVA hydrogels containing indomethacin of 1.5 mg/mL buffer solution was studied under several conditions: at the gelation temperatures of 2O-3O0C, the release temperatures of 27-47OC, and pHs of phosphate buffer solutions of 6.6-7.4, for the gels with the concentrations of PVA of 3-8% using the degree of polymerization of 2170-4380. Indomethacin has been released spending 14 h. The diffusion exponents were 0.45-0.50, corresponding to Fickian diffusion.

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