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Application of Supercritical Carbon Dioxide for the Preparation of Drug-Cyclodextrin Inclusion Compounds

✍ Scribed by T. Van Hees; V. Barillaro; G. Piel; P. Bertholet; S. De Hassonville; B. Evrard; L. Delattre


Book ID
110432504
Publisher
Springer Netherlands
Year
2002
Tongue
English
Weight
154 KB
Volume
44
Category
Article
ISSN
0923-0750

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Phase-solubility techniques were used to assess the formation of inclusion complex between itraconazole and beta-cyclodextrin. The stability constant and free energies of transfer of itraconazole from aqueous solution to the cavity of beta-cyclodextrin were calculated. Itraconazole solubility in sup