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Application of Stereocontrolled Stepwise [3+2] Cycloadditions to the Preparation of Inhibitors of α4β1-Integrin-Mediated Hepatic Melanoma Metastasis

✍ Scribed by Aizpea Zubia; Lorea Mendoza; Silvia Vivanco; Eneko Aldaba; Teresa Carrascal; Begoña Lecea; Ana Arrieta; Tahl Zimmerman; Fernando Vidal-Vanaclocha; Fernando P. Cossío

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 501 KB
Volume: 117
Category: Article
ISSN: 0044-8249
DOI: 10.1002/ange.200462497

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Application of Stereocontrolled Stepwise [3+2] Cycloadditions to the Preparation of Inhibitors of α4β1-Integrin-Mediated Hepatic Melanoma Metastasis

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Intravascular circulation of cancer cells represents a frequent event along neoplasic progression that seriously increases the probability of occurrence of metastasis. However, the adhesion of blood-borne cancer cells to the microvascular wall is a prerequisite for metastatic cell implantation at ta