✦ LIBER ✦
Application of Rhodium Complexes of Chiral Diphenylphosphino-Functionalized N-Heterocyclic Carbenes as Catalysts in Enantioselective Conjugate Additions of Arylboronic Acids
✍ Scribed by Jean-Michel Becht; Erhard Bappert; Günter Helmchen
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 72 KB
- Volume
- 347
- Category
- Article
- ISSN
- 1615-4150
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✦ Synopsis
Abstract
The Rh complex 1a of (S,S)‐1‐(2‐diphenylphosphanylnaphthalen‐1‐yl)‐3‐(2‐isopropylphenyl)‐4,5‐diphenylimidazolidin‐2‐ylidene was found to promote enantioselective conjugate additions of arylboronic acids to enones and α,β‐unsaturated esters with up to 98% yield and>99% ee. Products of the latter reaction can be transformed into GABA antagonists.