Application of quantitative structure–activity relationships (QSARs) for modeling drug and chemical transport across the human placenta barrier: A multivariate data analysis approach

Application of quantitative structure–ac

Application of quantitative structure–activity relationships for modeling drug and chemical transport across the human placenta barrier: a multivariate data analysis approach

✍ Costas Giaginis; Athina Zira; Stamatios Theocharis; Anna Tsantili-Kakoulidou 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 500 KB 👁 1 views

## Abstract Pharmacological agents and environmental pollutants can transfer from mother to fetus across the placental barrier, leading to reproductive toxic effects. __Ex vivo__ human placental perfusion constitutes the most widely used method to study placental transfer and metabolism of drugs an