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Application of olefin metathesis to the synthesis of ABE ring analogues of methyllycaconitine

✍ Scribed by David Barker; Malcolm D. McLeod; Margaret A. Brimble; G.Paul Savage

Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
75 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis

The synthesis of four novel ABE ring analogues of methyllycaconitine (MLA) is reported, employing olefin metathesis as the key step for appending the seven-membered B ring onto an AE bicyclic ring system. This strategy allows the stereodivergent synthesis of ABE ring analogues in which the stereochemistry of the AB ring junction is well defined. The compounds are designed as ligands to study binding and function of the a7-nAChR.

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