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Application of n.c.a. 4-[18F]fluorophenol in diaryl ether syntheses of 2-(4-[18F]fluorophenoxy)-benzylamines

✍ Scribed by Timo Stoll; Johannes Ermert; Shunichi Oya; Hank F. Kung; Heinz H. Coenen

Publisher
John Wiley and Sons
Year
2004
Tongue
French
Weight
148 KB
Volume
47
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The availability of no‐carrier‐added (n.c.a.) 4‐[^18^F]fluorophenol offers the possibility of introducing the 4‐[^18^F]fluorophenoxy moiety into potential radiopharmaceuticals. Besides alkyl–aryl ether synthesis using n.c.a. 4‐[^18^F]fluorophenol the diaryl ether coupling is an attractive synthetic method to enlarge the spectrum of interesting labelling procedures. As examples the syntheses of n.c.a. 2‐(4‐[^18^F]fluorophenoxy)‐N,N‐dimethylbenzylamine and n.c.a. 2‐(4‐[^18^F]fluorophenoxy)‐N‐methylbenzylamine were realized by an Ullmann ether synthesis of corresponding 2‐bromobenzoic acid amides using tetrakis(acetonitrile)copper(I) hexafluorophosphate as catalyst and a subsequent reduction of the amides formed. The radiochemical yield of the coupling varied between 5 and 65% based on labelled 4‐[^18^F]fluorophenol. Both compounds are structural analogues of recently published radiotracers for imaging the serotonin reuptake transporter sites (SERT). However, in vitro binding assays of both molecules showed only a low affinity towards monoamine transporters. Copyright © 2004 John Wiley & Sons, Ltd.

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