Application of Mosher's method for absolute configuration assignment and resolution of 2-hydroxypyrrolizidinones

✍ Scribed by Franca M. Cordero; Federica Pisaneschi; Maria Salvati; Silvia Valenza; Cristina Faggi; Alberto Brandi

• Publisher: John Wiley and Sons
• Year: 2005
• Tongue: English
• Weight: 173 KB
• Volume: 17
• Category: Article
• ISSN: 0899-0042
• DOI: 10.1002/chir.20139

✦ Synopsis

Abstract

Derivatization of racemic 2‐hydroxypyrrolizidinones with S‐(+)‐α‐methoxy‐α‐trifluoromethylphenylacetyl chloride (MTPA‐Cl) was successfully used for enantiomer separation and absolute configuration assignment. Chirality 17:149–153, 2005. © 2005 Wiley‐Liss, Inc.