✍ Scribed by Stefano Provera; Giuseppe Guercio; Lucilla Turco; Ornella Curcuruto; Giuseppe Alvaro; Tino Rossi; Carla Marchioro
No coin nor oath required. For personal study only.
Liquid chromatography‐NMR (LC–NMR) spectroscopy was used to obtain detailed information regarding the structure of the major bulk drug impurities present in GW597599 (vestipitant). The one‐dimensional ^1^H LC–NMR experiments were performed in both continuous and stop‐flow modes on a sample of GW597599 (vestipitant) enriched with mother liquor impurities. The information derived from both LC–NMR and LC–MS data provided the structural information of all major impurities. The full characterisation of the impurities by high‐resolution NMR spectroscopy was ultimately performed on appropriately synthesised compounds. Copyright © 2010 John Wiley & Sons, Ltd.
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Liquid chromatography (LC)-NMR spectroscopy was used to obtain detailed information regarding the structure of a bulk drug impurity present in glycinamide ribonucleotide transformylase (GART) inhibitor AG2034. The LC-NMR experiments (1D 1 H and 2D TOCSY) were performed in the stop-flow mode on crude