Application of L-Dopa as an Electroactive Ligand for Indirect Determination of Aluminum in Biological Samples by Differential Pulse Voltammetry
✍ Scribed by Fuping Zhang; Shuping Bi; Hongzhao Li; Yijun Chen; Lemei Dai
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 99 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1040-0397
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✦ Synopsis
A simple indirect method making use of 3,4-dihydroxyphenylalanine (L-dopa) as an electroactive complexation ligand for the determination of aluminum in biological samples at neutral pH on glassy carbon working electrode with differential pulse voltammetry (DPV) is reported. This method relies on the linear decrease of the DPV anodic peak current of L-dopa with the concentration of aluminum added. Under the optimum experimental conditions (pH 7.0, 0.08 M NH 4 Ac buffer solution, and 6610 74 M L-dopa), the linear range is 1-16610 76 M Al III . The detection limit is 8.9610 77 M and the relative standard deviation for 8.0610 76 M Al III is 3.9 % (n ¼ 8). Interference of foreign species relating to biological system has been inspected. The method has been applied to the measurement of aluminum in biological samples such as urine, hair, pork organs and consumption like drinking waters and synthetic renal dialysate. The possibility of the future application for in vivo detection of aluminum is also discussed.