Application of Fragment-Based Lead Generation to the Discovery of Novel, Cyclic Amidine β-Secretase Inhibitors with Nanomolar Potency, Cellular Activity, and High Ligand Efficiency §

✍ Scribed by Edwards, Philip D.; Albert, Jeffrey S.; Sylvester, Mark; Aharony, David; Andisik, Donald; Callaghan, Owen; Campbell, James B.; Carr, Robin A.; Chessari, Gianni; Congreve, Miles; Frederickson, Martyn; Folmer, Rutger H. A.; Geschwindner, Stefan; Koether, Gerard; Kolmodin, Karin; Krumrine, Jennifer; Mauger, Russell C.; Murray, Christopher W.; Olsson, Lise-Lotte; Patel, Sahil; Spear, Nate; Tian, Gaochao

• Book ID: 120228836
• Publisher: American Chemical Society
• Year: 2007
• Tongue: English
• Weight: 359 KB
• Volume: 50
• Category: Article
• ISSN: 0022-2623
• DOI: 10.1021/jm070829p