✦ LIBER ✦
Application of formal methods to biological regulatory networks: extending Thomas’ asynchronous logical approach with temporal logic
✍ Scribed by Gilles Bernot; Jean-Paul Comet; Adrien Richard; Janine Guespin
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 310 KB
- Volume
- 229
- Category
- Article
- ISSN
- 0022-5193
No coin nor oath required. For personal study only.
✦ Synopsis
Based on the discrete definition of biological regulatory networks developed by Rene´Thomas, we provide a computer science formal approach to treat temporal properties of biological regulatory networks, expressed in computational tree logic. It is then possible to build all the models satisfying a set of given temporal properties. Our approach is illustrated with the mucus production in Pseudomonas aeruginosa. This application of formal methods from computer science to biological regulatory networks should open the way to many other fruitful applications.