Application of discordant sib-pair linkage analysis for mapping minor histocompatibility antigen loci in a novel graft-vs-host-disease model

Strategy for mapping minor histocompatib

Strategy for mapping minor histocompatibility genes involved in graft-versus-host disease: A novel application of discordant sib pair methodology

✍ Kathryn L. Lunetta; John J. Rogus 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 153 KB 👁 1 views

We introduce a novel application for linkage analysis: using bone marrow donorrecipient sib pairs to search for genes influential in graft-versus-host disease (GVHD), a major cause of morbidity and mortality following allogeneic bone marrow transplantation. In particular, we show that transplant sib