Application of Denaturing Gradient Gel Electrophoresis to Detect DNA Sequence Differences Encoding Apolipoprotein E Isoforms

Exhaustive analysis of the P53 gene codi

Exhaustive analysis of the P53 gene coding sequence by denaturing gradient gel electrophoresis: Application to the detection of point mutations in acute leukemias

✍ J. M. Pignon; I. Vinatier; P. Fanen; P. Jonveaux; O. Tournilhac; M. Imbert; H. R 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 758 KB

We report the set-up of a denaturant gradient gel electrophoresis (DGGE) assay to screen for mutations in the whole coding sequence of the p53 gene. These DGGE experimental conditions were applied to the analysis of the p53 gene in acute leukemias. Forty adults with acute myelogenous leukemia (AML)