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Application of cybernetic models to metabolic engineering: Investigation of storage pathways

✍ Scribed by J. Varner; D. Ramkrishna

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
165 KB
Volume
58
Category
Article
ISSN
0006-3592

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✦ Synopsis

A cybernetic model is proposed to examine generic features of storage pathways. This model is capable of describing synthesis of carbon and non-carbon storage polymers. The effect of environmental conditions is evaluated using storage polymer level as a fraction of total biomass as a gauge of pathway performance. The base wild-type pathway is then analyzed to determine the effect of genetic alterations upon system performance. Proposed modifications are tested using the cybernetic model as a diagnostic tool to ascertain the ramifications of potential genetic alterations. A methodology is developed within the cybernetic framework to describe alterations of enzyme activity and overexpression of pathway enzymes.

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