Application of computer-assisted radiotelemetry in the pharmacokinetic and pharmacodynamic modeling of procainamide and N-acetylprocainamide
โ Scribed by Jahnavi Kharidia; Natalie D. Eddington
- Book ID
- 109388493
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 118 KB
- Volume
- 85
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The effect of moderate and prolonged exercise on the disposition and metabolism of drugs has not been extensively examined. The present study examined the effect of exercise training on the pharmacokinetics of procainamide and its active metabolite, N-acetylprocainamide. Male Sprague Dawley rats wer
Desethylamiodarone (DEA), the mjor active metabolite of amiodarone (AMD), plays a significant role in the electrophysiological effects observed during AMD thexapy. The pharmacokinetics and pharmacodynamics of DEA wcre studied in rats. Animals were administered DEA (20 or 40 mg kg-I) and blood sample